Prof. Dr. med. Jochen Roeper
Institut für Neurophysiologie (Physiologisches Institut II)
The group focusses on the physiology and pathophysiology of the dopaminergic midbrain system, which is involved in key brain functions like voluntary movement, motivation and cogition. The dopaminergic system is involved in major brain disorders like Parkinson diseases, Schizophrenia or ADHD. We study the mechanisms and chronic plasticity of ion channels and electrical activity generated by different subtypes of dopaminergic midbrain neurons and their role of function and dysfunction in the brain.
We mainly use in vitro and in vivo patch-clamp and microelectrode recordings in mouse brain combined with neuroanatomical tracing, stereology, immunohistochemistry and transgenic as well es neurotoxicological models.
Krabbe S, Duda J, Schiemann J, Poetschke C, Schneider G, Kandel ER, Liss B, Roeper J*, Simpson EH* (2015) Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area. PNAS 112:E1498-506. * shared senior authors